Public deliverables

This document is Deliverable 4.2 (“Report on existing HPV prevention programs”) of the CANCER PREVENTION AT WORK project. It is issued under the responsibility of the Regional Authority of Public Health, Banská Bystrica, Slovakia (RAPH BB) with the contribution of a working group comprising principal investigators and team members from the implementation centers in Slovakia, Italy, and principal investigators from partners in Denmark, Germany, Czech Republic and Spain.

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This document is Deliverable 4.1 (“HPV Study Initiation Package, including study protocol”) of the CANCER PREVENTION AT WORK project. It is issued under the responsibility of The Regional Authority of Public Health, Banská Bystrica, Slovakia (RAPH BB) with the contribution of a working group comprising principal investigators and team members from the implementation centers in Slovakia, Italy, and principal investigators from partners in Denmark, Germany, Czech Republic and Spain.

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This document is Deliverable 3.1 (“HCV Study Initiation Package, including study protocol”) of the CANCER PREVENTION AT WORK project. It is issued under the responsibility of The National Institute of Public Health, Bucharest, Romania (INSP) with the contribution of a working group comprising principal investigators and team members from the implementation centers in Italy, Romania, Slovakia and principal investigators from partners in Denmark, Germany, Czech Republic and Spain.

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In the context of global health, chronic infections such as Helicobacter Pylori (HP) significantly contribute to the gastric cancer burden. Addressing this, WP2 strategically focuses on integrating HP screening and eradication within occupational health surveillance programs. This integration serves as a primary preventive approach against gastric cancer, targeting both workers and their household members. The initiative is designed to evaluate the effectiveness and cost-efficiency of HP prevention in occupational health settings, while also investigating the prevalence and determinants of HP infection across various worker cohorts. A key aspect of WP2 is the promotion of awareness about HP-related diseases and the importance of prevention strategies. Furthermore, the project aims to develop and coordinate comprehensive plans for large-scale implementation of HP prevention, drawing insights from the results of pilot projects.

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The goal of this deliverable is to present a set of initial policy recommendations under the collaborative efforts from the 6 projects within the “Prevention and early detection” cluster of the Mission Cancer initiative, based on the Research and Innovation strand. This policy brief is intended to amplify the overall impact on the Mission Cancer’s aspirational objective of enhancing the lives of over 3 million individuals by 2030.

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Deliverable D7.8 presents the conclusions from the first annual meeting of the “Prevention and Early Detection Cluster” that took place on September 23rd, 2024, in Vienna jointly worked and agreed upon the common annual meeting. This report provides an overview of the Cluster and its projects, summarising the key presentations from its first annual meeting. It reviews updates on project progress, outlines ongoing activities within the Cluster’s Working Groups, and highlights planned actions for the second year.

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The stakeholder engagement plan (SEP) identifies key project stakeholders, included in the Stakeholder Forum (SF), and outlines the methodology and approach for interacting and communicating with them strategically over time, to increase the likelihood of positive outcomes.

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This document is Deliverable 5.1 (“Protocols of mixed-methods study on sociocultural, economic, and behavioural factors”) of the CANCER PREVENTION AT WORK (CPW) project. It is issued under the responsibility of the University of Southern Denmark (SDU) with the contribution of a working group comprising principal investigators and team members from work packages WP2, WP3, and WP4, as well as the project coordinator, Prof. Dr. Paolo Boffetta and the project manager Alessandra Cataneo, from the University of Bologna. 

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Adopting the TWH approach, coupled with household-based infection control and eradication strategies, can significantly reduce H. pylori prevalence, fostering a healthier workforce and diminishing long-term healthcare costs. The review underscores the importance of recognizing H. pylori as an occupational disease. It calls for further research into the “one-health” perspective on H. pylori transmission dynamics.

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Chronic infections such as Helicobacter pylori (Hp), Hepatitis B virus (HBV), Hepatitis C virus (HCV), and Human papillomavirus (HPV) are a major cause of gastric, liver, and HPV-related cancers that contribute significantly to the global burden of human cancers. Infections related to cancers can be prevented by preventing infection through vaccination, timely detection through screening, and eradication of the underlying infections. These strategies have proven effective in different countries, but the participation rates of vaccination, screening, and eradication programs for Hp, HCV, and HPV are less than optimal. Research has shown that participation rates are influenced by various social, cultural, economic, and personal barriers and facilitators. To uncover the current evidence and enhance the understanding of the factors of prevention of infections related to cancer, we conducted a systematic literature review of such barriers and facilitators. We searched Web of Science, PubMed, and Scopus databases to identify relevant original articles published between 2013 and 2023.

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